Immunotherapy in Recurrent Miscarriages, Implantation Failures & Unexplained infertility.
Dr. Mohan Raut MDDGO, Dr. (Mrs) Mugdha Raut MDDGO
Immunotherapy Centre for prevention of Repeated Miscarriages, Santacruz (E) Mumbai.
Recurrent Spontaneous abortions are detired as 3 or more consecutive spontaneous abortion it affects 0.5-1% of all women. In minority, parental chromosome abnormalities, uterine malformations or endocrine and thrombophilic disturbances may be the risk factors. However in 50-60% of these couples all these factors are normal. In these couples Immunological risk factors can be responsible for repeated miscarriages.
This has been increasingly considered because
Foetus is considered as an allograft. The paternal antigens of the foetus are always protected from maternal immunological system by complex combination of Humoral (blocking antibodies and cell mediated Immunity. This protects the foetus from immunological rejection by mothers immunological system. However deficiencies in these protective mechanism lead to an immunological response against the embryo leading to abortion or even implantation failure.
The Immunological factor in Recurrent miscarriages can be confirmed by doing certain tests the tests are based on following observations..
Two Kinds of Immunotherapy are used in patients with RM & Implantation Failure
(A) Active Immunotherapy –
LIT or Lymphocyte Immunization Therapy.
(B) Intravenous Immunoglobulins.
Lymphocytes from husband or pooled Donor Lymphocytes are used to cause Immuno modulation in the mother leading to prevention of repeated miscarriages.
LIT is more effective in primary aborters ( no live baby)
(B) Intravenous Immunologlobulin (IvIg) IvIg is used to prevent repeated miscarriages and is especially effective in secondary aborters.
Immunotherapy for RSA and Implantation Failure has been practiced across the globe. There are trials which have shown definite effectiveness of Immunotherapy in these cases ( Dr.O.B.Christiansen, Pandey Mk etc) A Cochrane metanalysis of relevant trials had concluded that LIT provide no significant beneficial effects However Dr O.B Christiansen in his analysis of cochrane review has proved that the mataanalsis was flawed and showed that LIT was in fact more effective in primary Aborters. Also effect of LIT increased with the number of previous miscarriages.
Recently Immunotherapy Foundation & Immunotherapy Centre for Prevention of Repeated Miscarriages was launched in Mumbai. Dr. O.B Christiansen was the guest speaker and in his speech he explained in details about various types of Immunotherapys and their effectiveness .
LIT is available at Immunotherapy Centre for Prevention of Repeated Miscarriages located at Santacruz (E), Mumbai A complete Immunological Profile work up is done prior to selecting couples for Immunotherapy. LIT is a day care procedure involving 4-6 hours of Hospital stay.
Repeated Miscarriages is a strattering experience for a couple. After treating the couples who have known risk factor a large number of couples remain in whom Immunological factor is responsible. A proper diagnostic work up followed by appropriate Immunotherapy can help these couples achieve their dream of having a healthy baby.
397 couples were given Active Immunotherapy. (LIT) These included couples with repeated miscarriages, & Implantation Failures (IVF). The success rate reported was 85%. This study has encouraged us to start ICPRM.
The lyers went form clinic to clinic . They tried everything,including IVF. Nothing worked.But they were not the ones to give up hope! Finally,after 5 years of waiting,Nisha was born to them at our clinic.
An open letter from Dr Mugdha
Nisha is 21 now! she is hale and hearty; beautiful to look at and very very spirited. To me, she could have been no one other than that - knowing first hand how she was brought into the world.
It is beautiful story I love to tell,especially to those couples who have resigned to a life without a child.Read More
There are half a million cases where IVF has failed too;but that no way means the end of the road to parenthood. Dr Mohan Raut writes about his experience with Lymhocyte Immunisation Therapy.Read More